Reference List

BioPAL's Family of Imaging Products

Below are a list of references from researchers that have used and referenced BioPAL's USPIO imaging products. If you have a paper that references a BioPAL MRI product, please let us know.

Molday ION™ - Vascular Imaging Application

Title of Article PubMed
Comparison of Three Ultrasmall, Superparamagnetic Iron Oxide Nanoparticles for MRI at 3.0 T.
Functional specialization of macaque premotor F5 subfields with respect to hand and mouth movements: A comparison of task and resting-state fMRI.
Investigation of the BOLD and CBV fMRI responses to somatosensory stimulation in awake marmosets (Callithrix jacchus).
Two areas for familiar face recognition in the primate brain.
A dedicated network for social interaction processing in the primate brain.
Repeatability and sensitivity of high resolution blood volume mapping in mouse kidney dissase.
MRI confirms loss of blood-brain barrier integrity in a mouse model of disseminated candidiasis.
Low-field paramagnetic resonance imaging of tumor oxygenation and glycolytic activity in mice.
Neural basis of global resting-state fMRI activity.
Estimation of tumor microvessel density by MRI using a blood pool contrast agent.
Noninvasive imaging of the functional effects of anti-VEGF therapy on tumor cell extravasation and regional blood volume in an experimental brain metastasis model.
Vessel imaging with viable tumor analysis for quantification of tumor angiogenesis.
Quantitative pharmacologic MRI in mice.
Ultrasmall superparamagnetic iron oxide (USPIO)-based liposomes as magnetic resonance imaging probes.
Longitudinal imaging studies of tuor microenvironment in mice treated with the mTOR inhibitor rapamycin.

Molday ION™ - Cell Labeling, Tracking and Magnetic Retention Applications

Title of Article PubMed
Optimal technique for canine mesenchymal stem cells labeling with novel SPIO, MIRB™: for MRI detection of transplanted stem cells canine stroke model.
Use of magnetotactic bacteria as an MRI contrast agent for in vivo tracking of adoptively transferred immune cells.
Tracking of stem cells from human exfoliated deciduous teeth labeled with Molday ION Rhodamine-B during periodontal bone regeneration in rats.
Human integrin α10β1-selected mesenchymal stem cells home to cartilage defects in the rabbit knee and assume a chondrocyte-like phenotype.
Evaluation of the therapeutic efficacy of human bone marrow mesenchymal stem cells with COX-2 silence and TGF-β3 overexpression in rabbits with antigen-induced arthritis.
Human bone marrow mesenchymal stem cell-derived extracellular vesicles attenuate neuroinflammation evoked by focal brain injury in rats.
Labeling of human mesenchymal stem cells with different classes of vital stains: robustness and toxicity.
Enhanced Homing of Mesenchymal Stem Cells Overexpressing Fibroblast Growth Factor 21 to Injury Site in a Mouse Model of Traumatic Brain Injury.
Safety and Feasibility of Intrastromal Injection of Cultivated Human Corneal Stromal Keratocytes as Cell-Based Therapy for Corneal Opacities.
Imaging of extracellular vesicles derived from human bone marrow mesenchymal stem cells using fluorescent and magnetic labels.
In vitro labelling and detection of mesenchymal stromal cells: a comparison between magnetic resonance imaging of iron-labelled cells and magnetic resonance spectroscopy of fluorine-labelled cells.
Rat endothelial progenitor cells labeled with Molday ION EverGreen and in vitro MRI study.
External magnetic field promotes homing of magnetized stem cells following subcutaneous injection.
Biological Characteristics of Fluorescent Superparamagnetic Iron Oxide Labeled Human Dental Pulp Stem Cells.
In vivo quantification of magnetically labelled cells by MRI relaxometry.
Long-Term Cell Tracking following Local Injection of Mesenchymal Stromal Cells in the Equine Model of Induced Tendon Disease.
SIRB, sans iron oxide rhodamine B, a novel cross-linked dextran nanoparticle, labels human neuroprogenitor and SH-SY5Y neuroblastoma cells and serves as a USPIO cell labeling control.
Cell-based therapy in TBI: Magnetic retention of neural stem cells in vivo.
Combining perfluorocarbon and superparamagnetic iron-oxide cell labeling for improved and expanded applications of cellular MRI.
Impacts of fluorescent superparamagnetic iron oxide (SPIO)-labeled materials on biological characteristics and osteogenesis of bone marrow mesenchymal stem cells (BMSCs).
In vivo visualization and ex vivo quantification of murine breast cancer cells in the mouse brain using MRI cell tracking and electron paramagnetic resonance.
Site-specific targeting of platelet-rich plasma via superparamagnetic nanoparticles.
In vivo tracking and fate of intraarticularly injected superparamagnetic iron oxide particle-labeled multipotent stromal cells in an ovine model of osteoarthritis.
In vivo tracking of novel SPIO-Molday ION Rhodamine-BTM-labeled human bone marrow-derived mesenchymal stem cells after lentivirus-mediated COX-2 silencing: a preliminary study.
In vitro self-assembly of human pericyte-supported endothelial microvessels in three-dimensional coculture: a simple model for interrogating endothelial-pericyte interactions.
Therapeutics with SPION-labeled stem cells for the main diseases related to brain aging: a systematic review.
Umbilical cord mesenchymal stem cells labeled with multimodal iron oxide nanoparticles with fluorescent and magnetic properties: application for in vivo cell tracking.
Comparative labelling of equine and ovine multipotent stromal cells with superparamagnetic iron oxide particles for magnetic resonance imaging in vitro.
Human neural progenitor cells retain viability, phenotype, proliferation, and lineage differentiation when labeled with a novel iron oxide nanoparticle, Molday ION Rhodamine B.
Use of MR cell tracking to evaluate targeting of glial precursor cells to inflammatory tissue by exploiting the very late antigen-4 docking receptor.
Investigation of cellular and molecular responses to pulsed focused ultrasound in a mouse model.
Long-term MR cell tracking of neural stem cells grafted in immunocompetent versus immunodeficient mice reveals distinct differences in contrast between live and dead cells.
Mesenchymal stem cell labeling and in vitro MR characterization at 1.5 T of new SPIO contrast agent: Molday ION Rhodamine-B™.
Tracking cell fate with noninvasive imaging.
What lies beneath: in vivo stem cell imaging.
Labeling of multiple cell lines using a new iron oxide agent for cell tracking by MRI.
Labeling of cynomolgus monkey bone marrow-derived mesenchymal stem cells for cell tracking by multimodality imaging.
Use of MR cell tracking to evaluate targeting of glial precursor cells to inflammatory tissue by exploiting the very late antigen-4 docking receptor.
Study of internalization and viability of multimodal nanoparticles for labeling of human umbilical cord mesenchymal stem cells.
Concurrent dual contrast for cellular magnetic resonance imaging using gadolinium oxide and iron oxide nanoparticles.
MR monitoring of minimally invasive delivery of mesenchymal stem cells into the porcine intervertebral disc.
Assessment of biological characteristics of adipose tissue-derived stem cells co-labeled with Molday ION Rhodamine B™ and green fluorescent protein in vitro.

Dual MRI and PET/SPECT Imaging

Title of Article PubMed
Tumor Lysing genetically engineered T cells loaded with multi-modal imaging agents.

Molday ION™ Applications Using USPIOs Having Functional Surfaces

Title of Article PubMed
Targeting GLP-1 receptors for repeated magnetic resonance imaging differentiates graded losses of pancreatic beta cells in mice.
Development and characterization of antibody-labeled super-paramagnetic iron oxide contrast agent targeting prostate cancer cells for magnetic resonance imaging.
Decreased reticuloendothelial system clearance and increased blood half-life and immune cell labeling for nano- and micron-sized superparamagnetic iron-oxide particles upon pretreatment with Intralipid.

BioPAL, Inc. • 80 Webster Street Worcester, MA 01603 • TEL: 508-770-1190 • FAX: 508-770-1191 • e-mail:

© copyright 2013 • All Rights Reserved