Innovation
New ways to make measurements
in the life sciences!

BioPAL is focused on developing and
commercializing novel tools for the life science and biomedical communities. Most of our products and technology platforms can be found nowhere else.
Kidney Diagnostic
BioPAL offers immunoassay kits to measure
the renal clearance of ideal filtration markers
to obtain an accurate GFR or RBF measurement.

• Inulin GFR kits

• Iohexol GFR kits

• Gd-DOTA GFR kits and Gd-DTPA GFR kits

• Iodohippurate RBF kits
MRI Contrast Agents
BioPAL is a leading provider of novel MRI contrast
reagents directed toward the needs of the life
science community.

• Gadolinium products - T1 imaging agents

• Iron products - T2 imaging agents
Neutron Activation Analysis
BioPAL is the first company to develop and provide
in vivo diagnostic products based on NA technology
as the readout system.

• Microspheres

• Nanoparticles

• Protein labeling kits

Gado CELLTrack™

Technical Information

BioPAL has developed Gado CELLTrack™ to aid researchers locate, track and quantify implanted cells in in vivo systems using magnetic resonance imaging (MRI) technology. Gado CELLTrack is a 50 nm gadolinium colloid. As shown in the figure below, this reagent provides a strong T1 brightening signal that is at minimum comparable to the same molar concentration as Gd-DTPA. In addition, BioPAL can provide this reagent containing a small amount of other isotopes to allow for quantification via neutron activation.

FOR RESEARCH USE ONLY.
NOT FOR USE IN DIAGNOSTIC PROCEDURES.

Stem cell labeling imaging and tracking via MRI and is a better alternative to GadofluorineM. Cell tracking agent for T1 MRI imaging. A gadolinium nanoparticle for cell labeling and MRI tracking.

Phantom Study

gadolinium colloid for cell labeling and MRI imaging

The above Figure shows the T1 weighted image from a series of compounds having the same molar concentration are shown on the left and normalized intensity values are tabulated on the right. Row 1 is Gd-DTPA, Row 2 is BioPAL's colloidal gadolinium reagent (Gado CELLTrack), Row 3 is BioPAL's colloidal europium reagent having the same size and matrix as colloidal gadolinium, and Row 4 is PBS. The R1=4 for Gd-DTPA and R1=5 for Gado CELLTrack.

Published Reference

Relaxation Values

Using Poly-L-Lysine

The Product

Two ml of Gado CELLTrack™ is packaged in a 2 ml sealed serum bottles. The product is a 50nm gadolinium colloid (10 mg Gd/ml) having a negative surface. BioPAL also provides poly-L-Lysine (1 ml, 10 gm/ml) packaged in a 2 ml sealed serum bottle.

The procedure for labeling poly-L-Lysine onto Gado CELLTrack™ is comparable to the procedure described for Molday ION (-) (CL-30Q02-6), but may require an initial range finding study for optimal labeling for each cell tpye. This procedure is provided as a PDF download above.

Cat. No.	Product Name	Price (US)	MSDS
CL-50P02-6	Gado CELLTrack™	$450.00
CL-00-01	Poly-L-Lysine	$60.00

Gado CellTrack is a cell labeling product to label cells and then track cells and image cells using MRI imaging. Primary cells, T-cells, stems cells and platelets can be labeled, imaged and tracked using T1 MRI imaging.

BioPAL, Inc. • 80 Webster Street Worcester, MA 01603 • TEL: 508-770-1190 • FAX: 508-770-1191 • e-mail: cs@BioPAL.com